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Original Research Article | OPEN ACCESS

Potentiation of raloxifene cytotoxicity against MCF-7 breast cancer cell lines via transdermal delivery and loading on self-emulsifying nanoemulsions

Hibah M Aldawsari1 , Aya A Negm2

For correspondence:-  Hibah Aldawsari   Email: dr.hibah2018@hotmail.com   Tel:+966543627789

Accepted: 22 December 2019        Published: 31 January 2020

Citation: Aldawsari HM, Negm AA. Potentiation of raloxifene cytotoxicity against MCF-7 breast cancer cell lines via transdermal delivery and loading on self-emulsifying nanoemulsions. Trop J Pharm Res 2020; 19(1):11-15 doi: 10.4314/tjpr.v19i1.5

© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To enhance raloxifene (RLX) delivery and cytotoxicity against breast cancer (MCF-7) cell lines.
Methods: This was a solubility study of RLX in different oils, surfactants, and co-surfactants. Twelve formulae were tested to reach the smallest globular size, and hydroxypropyl methylcellulose, (HPMC), and Carbopol 947 polymers were tested for formation of transdermal films. The formula with the lowest size was compared with raw RLX in diffusion studies using a Franz diffusion cell. Finally, a cytotoxicity study against MCF-7 breast cancer cell lines was conducted
Results: The maximum solubility of RLX was in Tween 80, peppermint oil, and PEG 200; therefore, these were the main components of the 12 formulations. The release of RLX loaded on the self-nanoemulsion drug delivery system (SNEDDS) was increased 3-fold compared with raw RLX. Cytotoxicity results revealed that RLX SNEDDs decreased MCF-7 cell survival by approximately 40 %, compared with raw RLX (control), which augmented the RLX suppression of breast cancer cell lines.
Conclusion: Improvement in RLX cytotoxicity is a novel strategy to suppress breast cancer.

Keywords: Raloxifene, Osteoporosis, Bioavailability, Nanoemulsion, Nanoparticles

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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